營養素攝取/GNB3 C825T基因多型性與懷孕婦女體重變化之相關性研究

There are many studies investigating relations among nutrient intake，weight changes during pregnancy and birth outcomes。 However，very few studies examining associations between obesity-related gene polymorphism and weight changes during pregnancy。The purpose of the current study is to examine associations among energy/macronutrient intake，GNB3 C825T polymorphism，weight chane during pregnancy and birth outcomes。 This is a cohort study。During period of July 1994 ~February 1996。 There were total 105 singlet pregnant women completing the experiment。 The nutrient intake during 1st and 3rd trimesters were collected using 24 hour dietary recall and weight parameters of pregnant women were monitored throughout pregnancy。 Net weight changes (WC) were defined as (weight before pregnancy (kg) – weight (kg) measured before pregnancy)。 % of weight change (PWC) is defined as (weight before pregnancy (kg) – weight (kg) measured before pregnancy)/ weight before pregnancy (kg) * 100%。 No significant associations were found between energy/macronutrient intake in 1st and 3rd trimester and WC or PWC。 There were positive relations between protein intake (g) in 3rd trimester and birth length (r=0.19，p=0.04)；negative associations were found between 1st trimester fat intake and birth head circumference (r=-0.20，p=0.04)。 With regard to relatioships between pregnant-related weight parameters and birth outcome， WC was associated with birth weight (r=0.19，p=0.04)、birth length (r=0.22，p=0.02) and placenta weight (r=0.21，p=0.04)；no assoctions were observed between PWC and the birth outcomes。 The distribution of GNB3 C825T of 105 subjects were CC genotype：24.8％(n=26)、CT genotype：52.4％(n=55) and TT genotype：22.9％(n=24)。There were significant differences in PWC among CC genotype（22.1%）、CT genotype（24.4%）and TT genotype（27.2%）in a dose response manner (p for trend= 0.02)。Prepregnant weight (kg) were decreased（CC=57.1kg，CT=54.6kg，TT=53.3kg）and WC（CC=12.6kg， CT=13.1kg， TT=14.3kg）were decreased among CC genotype， CT genotype and TT genotype accordingly，however，the trends did not reach statistically significant。 No associations were observed between GNB3 C825T gene polymorphism and birth outcomes。To further confirm relationships between nutrient intake weight change during pregnancy， larger sample size may be needed to overcome bias derived from dietary recall。 Further，GNB3 C825T gene polymrophism seems to related to some weight change parameters during pregnancy，increased sample size is also needed to further clarify their associations。