Abstract 12330: Effects of Diabetes on Left Ventricular Diastolic Dysfunction in Patients with Hypertension; A Substudy of Calvloc Study

Background: Coexistence of diabetes mellitus (DM) worsens prognosis of hypertensive patients, but its mechanisms are still not fully elucidated. We previously performed a multicenter trial (CALVLOC trial) which demonstrated that a calcium channel blocker, azelnidipine, improves left ventricular (LV) relaxation in patients with hypertension and diastolic dysfunction (Hypertens Res 32;895, 2009). As a substudy of CALVLOC trial, we investigated (1) how DM would affect diastolic function in hypertensive patients (2) whether azelnidipine also would improve LV relaxation in patients with DM and hypertension. Methods and Results: We enrolled 228 hypertensive patients with normal ejection fraction and impaired LV relaxation, as defined as early-diastolic mitral valvular velocity (e’) less than 8 cm/s. We administered 16mg of azelnidipine for 8 months (range: 6-10 month). We performed echocardiography at baseline and at 8 month later, and determined e’ and an E/e’ ratio as diastolic parameters. DM was diagnosed in...