Abstract 263: Changes in Cerebral Oxygen Metabolism and Hemodynamics During ECPR with Therapeutic Hypothermia Measured by Near Infrared Spectroscopy

(Background) For protection of the brain, hypothermia is a helpful therapeutic approach in patients who remain comatose after return of spontaneous circulation (ROSC). The 2010 CPR Guidelines recommend that extracorporeal cardiopulmonary resuscitation (ECPR) using an emergency cardiopulmonary bypass (CPB) should be considered for patients with cardiac arrest. However, it is not yet clear whether this therapy can improve cerebral circulation and oxygenation in these patients. To clarify this issue, we evaluated change of cerebral blood oxygenation (CBO) during ECPR using near-infrared spectroscopy (NIRS). (Methods) Between November 2009 and June 2011, we employed NIRS (NIRO-200NX, Hamamatsu Photonics, Japan) to measure CBO in the bilateral frontal lobe in patients transported to the ER after out-of-hospital cardiac arrest. Enrollment criteria were: aged 18-74 years; cardiac arrest witnessed by bystanders; presumed cardiac etiology of cardiac arrest according to the Utstein style guidelines; estimated time ...