Diagnostic performance and prognostic value of serum troponin T in suspected acute myocardial infarction

Ravkilde J, Herder M, Gerhardt W, Ljungdahl L, Pettersson T, Tryding N, Mailer B.H, Hamfelt A, Graven T, Asberg A, Helin M, Penttila I, Thygesen K. Diagnostic performance and prognostic value of serum troponin T in suspected acute myocardial infarction. Scand J Clin Lab Invest 1993; 53: 677-685.Cardiac troponin T (TnT) is a new serological marker for use as a diagnostic tool for myocardial damage. A blinded prospective multicentre study representing 298 patients suspected of having acute myocardial infarction (AMI), and admitted to the coronary care units of six Scandinavian Hospitals was undertaken to assess the diagnostic performance and prognostic efficacy of a new cardiospecific TnT immunoassay. We used a discriminator TnT value of 0.20μg 1−1. One hundred and fifty five patients (52%) had definite AMI, based on WHO criteria (all had peak S-TnT values of ≥ 0.20 μg 1−1); 127 patients (43%) had ischaemic heart disease (IHD) without AMI; and 16 patients (5%) had non-IHD (all had peak S-TnT values of <0.20...