Association of Laboratory data on Lifestyle-related Factors with the Risk of Colorectal Adenoma and Cancer: A Retrospective Cohort Study with Long-term Follow-up Total Colonoscopy

AIM: Lifestyle-related factors, in particular hyperglycemia, have been positively related to the risk of colorectal adenoma or cancer in most, but not all, studies. METHODS: We conducted a retrospective cohort study using data from 611 individuals who had at least 10-year follow-up with total colonoscopy for colorectal adenoma or cancer. Blood glucose, cholesterol, triglycerides, and uric acid as “lifestyle-related factors” were measured in all patients at their first TCS. RESULTS: By Kaplan-Meier analysis, comparing the cumulative incidence of colorectal adenoma or cancer, the rate in cases with a blood glucose level of 110 mg/dL or more was significantly higher than in cases with less than 110 mg/dL (p=0.013 by the log-rank test, glucose 50 years) and in the adenoma and cancer groups (HR, 1.4, 95% CI, 1.09–1.71; HR, 1.3, 95% CI, 0.98–1.63). CONCLUSION: Our results suggest that hyperglycemia increases the risk of colorectal adenoma or cancer in Japanese adults as determined by long-term follow-up with total colonoscopy.