Optimizing strategies in pancreatic and hepato-biliary surgery

This thesis aims to improve perioperative strategies in HPB surgery. Part I focuses on finding the optimal analgesic strategy and investigates the impact of continuous wound infiltration (CWI) versus epidural analgesia. Part II includes studies on one of the most threatening complications of pancreatic surgery: postoperative pancreatic fistula (POPF). Part III consists of studies on worldwide perioperative practices in liver surgery, fluid therapy, new-onset diabetes after pancreatoduodenectomy (PD), and outcome prediction in HPB surgery.