Activation of μ opioid receptors modulates inflammation in acute experimental colitis

Background l opioid receptors (lORs) are expressed by neurons and inflammatory cells, and mediate immune response. We tested whether activation of peripheral lORs ameliorates the acute and delayed phase of colitis. Methods C57BL/6J mice were treated with 3% dextran sodium sulfate (DSS) in water, 5 days with or without the peripherally acting lOR