Effects of calcium channel blocker MN9201 on hemodynamics of rabbits

AIM: To study the hemodynamic effects of a novel dihydropyidine calcium channel blocker, methyl pentyl 1,4-dihydro-2,6-dimethy l, 4-(3-nitrophenyl)-3,5-pyridenedicarboxylate (MN9202), on anaesthetic rabbits. METHODS: Rabbits were anaesthetized with sodium pentobarbitone. Three polyethylene catheters were inserted into the left ventricular cavity, femoral artery and inferior vena cava, respectively. Blood flow of aortic artery was detected by electric-magnetic flowmeter. Hemodynamic indexes of anaesthetic rabbits were collected and the effects of MN 9202 were analyzed by an affiliated computer in real time. RESULTS: MN9202 was given in an accumulated doses of 1,5 and 10 μg/kg at 10 min intervals. MN9202 exerted significant hemodynamic effects in a dose-dependent manner. With an increasing size of MN9202 dosage, blood preasure and total peripheral resistance of rabbits declined. In the meantime, cardiac output was increased, affecting the improvement of heart function. CONCLUSION: MN9202 has strong and prolonged effects on the hemodynamic indexes of the rabbits .