Abstract 20382: Long-Term Follow-Up After NIRS Coronary Imaging: Insights From the ORACLE-NIRS Registry

Introduction: Near-infrared spectroscopy (NIRS)-measured coronary lipid burden may be associated with the incidence of subsequent cardiovascular events. We sought to evaluate long-term outcomes after NIRS imaging. Methods: We analyzed data from 241 patients participating in the ORACLE-NIRS registry who underwent NIRS coronary imaging during clinically-indicated cardiac catheterization from 2009-2011. NIRS was performed in vessels that did and did not undergo percutaneous coronary intervention (PCI). Results: Mean patient age was 64 ± 9 years, 99% were men and 50% were diabetic, presenting with stable angina (51%) or an acute coronary syndrome (ACS, 49%). Pre-intervention NIRS data from 118 target vessels and 38 non-target vessels in 139 patients was available. Median lipid core burden index (LCBI) of PCI target vessels was 87 [interquartile range, IQR 48-129]. Median LCBI in non-target vessels was 59 [IQR 29-98]. During a median follow-up of 5.7 years the incidence of major adverse cardiovascular events (...