Validity of the Global Registry of Acute Coronary Events risk score in prediction of acute myocardial infarction mortality in hospitalised Chinese patients aged 80 and over

Aim To detect the validity of the Global Registry of Acute Coronary Events (GRACE) risk score in predicting acute myocardial infarction (AMI) mortality of Chinese inpatients aged 80 and over. Method Hospital mortality was defined as all-cause death rate of patients during hospitalisation. Using GRACE risk score to predict death risk, both discrimination (C statistic) and calibration (the predicted vs observed mortality based on the population with predicted risks) were evaluated. Results Three hundred eighty-six patients presenting with ST segment elevation AMI (STEMI) and non-STEMI were enrolled. The GRACE risk score ranged between 151 and 297, and the mortality was 23.3%. The overall discriminatory capacity of the GRACE model was high (C statistic 0.767, CI: 0.712–0.822). There was a high correlation (R2 = 0.833) between the predicted and observed hospitalised AMI mortality. Conclusion The GRACE score is a useful risk prediction model for hospital mortality of Chinese AMI patients aged 80 and over.