INFLUENCE OF CLINICAL TRIAL SITE ENROLLMENT ON PATIENT CHARACTERISTICS, PROTOCOL COMPLETION, AND ENDPOINTS: INSIGHTS FROM THE ASCEND-HF TRIAL

Stephen J. Greene,Adrian F. Hernandez,Jie Lena Sun,Marco Metra,Javed Butler,Andrew P. Ambrosy,Justin Ezekowitz,Randall Starling,John Teerlink,Adriaan Voors,Paul W. Armstrong,Christopher M. O'Connor,Robert J. Mentz

INFLUENCE OF CLINICAL TRIAL SITE ENROLLMENT ON PATIENT CHARACTERISTICS, PROTOCOL COMPLETION, AND ENDPOINTS: INSIGHTS FROM THE ASCEND-HF TRIAL

2016

Stephen J. Greene
Adrian F. Hernandez
Jie Lena Sun
Marco Metra
Javed Butler
Andrew P. Ambrosy
Justin Ezekowitz
Randall Starling
John Teerlink
Adriaan Voors
Paul W. Armstrong
Christopher M. O'Connor
Robert J. Mentz

Most recent international acute heart failure (AHF) trials have failed to show benefit with respect to key endpoints. The influence of site enrollment and protocol execution on trial performance is unclear. We assessed the impact of site enrollment volume on patient (pt) characteristics, protocol

Keywords:

Clinical trial
Physical therapy
Medicine
Cardiology
Internal medicine
Diabetes mellitus
Heart failure
patient characteristics
Emergency medicine

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