The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

Tomohiro Okamoto,Yoko Ozawa,Mamoru Kamoshita,Hideto Osada,Eriko Toda,Toshihide Kurihara,Norihiro Nagai,Kazuo Umezawa,Kazuo Tsubota

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

2016

Tomohiro Okamoto
Yoko Ozawa
Mamoru Kamoshita
Hideto Osada
Eriko Toda
Toshihide Kurihara
Norihiro Nagai
Kazuo Umezawa
Kazuo Tsubota

Purpose The determination of the molecular mechanism underlying retinal pathogenesis and visual dysfunction during innate inflammation, and the treatment effect of rapamycin thereon.

Keywords:

PI3K/AKT/mTOR pathway
Inflammation
Sirolimus
Immunology
Retina
Retinal
Pathogenesis
Cancer research
NF-κB
Neuroprotection
Medicine

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