SIRS and MODS in Acute Pancreatitis

Acute pancreatitis is a serious illness characterized by acute inflammation of the pancreatic acinar gland cells. Loss of local control or exaggerated inflammation will cause an inflammatory response of the body that can be of two kinds: systemic pro-inflammatory response syndrome or compensatory anti-inflammatory response syndrome. The imbalance caused by the influences of two types of body responses produces numerous serious clinical and biological consequences. In the final stage of the disease, due to inefficient or excessive compensatory anti-inflammatory reaction, immunosuppression and multiple organ dysfunction (MODS) with increased morbidity and mortality set in. Dysfunctions encountered in MODS are numerous: cardiovascular, respiratory, renal, hepatic, hematological, intestinal, neurological and metabolic. Conclusion: It is important