Intravitreal tigecycline treatment in experimental Acinetobacter baumannii endophthalmitis.

AbstractPurpose: To investigate the clinical and microbiological effectivity of intravitreal tigecycline in an experimental rabbit endophthalmitis model caused by imipenem resistant Acinetobacter baumannii.Materials and Methods: Forty-eight eyes of 24 New Zealand white albino rabbits were divided into six groups (n = 8 in each). The right eyes were divided into three groups and defined as infected group; left eyes were divided into three groups and defined as uninfected group. Infected group received 0·1 ml intravitreal A. baumannii suspension. Twenty-four hours after bacterial inoculation, group 1 received 1 mg/0·1 ml tigecycline and group 2 received 0·5 mg/0·1 ml tigecycline. Group 3 eyes received no treatment. In group 4, 0·1 ml of saline solution was injected. Groups 5 and 6 were received intravitreal tigecycline injection of 1 mg/0·1 ml and 0·5 mg/0·1 ml respectively. The eyes were enucleated for histopathological evaluation on the sixth day. Clinical and histological scoring systems were used to eva...