PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma

Integrins and downstream signaling kinases, such as proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK), are important for sensing cell adhesion to the extracellular matrix and were demonstrated to be involved in multiple myeloma (MM) progression, dissemination and drug resistance