386. Long-term Complications Associated with COVID-19 Infection

Background: In Michigan, 44,964 (68%) of the 66,269 COVID-19 patients have recovered However, there is concern that COVID-19 infection may lead to long-term sequelae, including pulmonary defects, cardiac complications, blood clots, and neurocognitive impairment This study describes the 30-day outcomes of patients who had recovered Methods: From 3/16/2020 to 5/19/2020, a follow-up was attempted for patients who were discharged alive from Henry Ford Hospital in Detroit and had recovered Recovery was defined as being alive 30 days post symptom-onset A telephone survey was conducted 30 days post-index admission and recorded in electronic medical records Oxygen (O2) requirements, symptoms, readmissions and the need for antibiotics for secondary bacterial infections were evaluated Results: 585 patients met inclusion criteria and were contacted by phone;303 answered their phone (Table 1), but only 266 (45%) completed a full telephone encounter and were included in the final analysis (Table 2) The majority were female (53%), black (80%), and discharged to home (84%) The clinical characteristics of those who completed the survey were as follows: 11% presented with O2 saturation < 90%, 16% had underlying lung pathology, and 57% had a BMI above 30 Patients' average age was 61 ± 14 3 years At 30 days post-index admission, 49% were still symptomatic Of the symptomatic patients, 86% had dyspnea on exertion and 15% required O2 supplementation 18% of patients were readmitted within 30 days, and 9% developed a secondary infection prior to the phone encounter No statistically significant differences in demographics or comorbidities were found between symptomatic and asymptomatic cohorts (Tables 1, 2) Conclusion: In our study, almost half of the discharged patients remained symptomatic after 30 days with a substantial proportion experiencing pulmonary symptoms A better understanding of the long-term pulmonary sequelae following COVID-19 infection is needed to design interventions to reduce post-infectious morbidity