Preparation of Anethol trithione solid dispersions by hot-melt extrusion technology

OBJECTIVE To prepare anethol trithione(ATT) solid dispersions.METHODS The anethol trithione solid dispersions with Plasdone S630 or Poloxamer as carriers were prepared by hot-melt extrusion method.The solid dispersions were characterized by differential scanning calorimetry(DSC),X-ray powder diffraction(XRPD).The in vitro dissolutions of ATT tablets at an initial 6 months storage under the condition of 40 ℃/75% RH were investigated.RESULTS The order of dissolution rates were observed:ATT-Plasdone S630Danweita(reference tablets)ATT-Poloxamer 188physical mixture.DSC and XRPD showed that the drug was present as amorphous or molecule state in Plasdone S630,as crystalline in Poloxamer 188.Stability of dissolution profiles showed that ATT-Plasdone S630 tablets were more stable than ATT-Poloxamer 188 tablets.CONCLUSION Plasdone S630 is a better selection for hot-melt extrusion method to prepare of anethol trithione as solid dispersions carrier.