WESTERN DIET INDUCED OBESITY INCREASES OXIDATIVE STRESS IN THE HEART BY IMPAIRING THE NRF2 ANTIOXIDANT RESPONSE PATHWAY

One of the earliest manifestations of obesity related CVD is diastolic dysfunction leading to heart failure with preserved ejection fraction (HFpEF). A limitation in developing therapy for HFpEF is poor mechanistic insight behind development of diastolic dysfunction in obesity. It is shown that a