Brain ischemia and spreading depression in a primate model

In order to investigate the pathophysiology of ischemic stroke, we developed a primate thromboembolic stroke model and examined serial changes in cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMRglc) using positron emission tomography (PET). In addition, we attempted to elicit spreading depression (SD), which is essential in the evolution of infarcts in small animal models, by chemical stimulation in primates.