Preparation method and application of fluorescence mesoporous silica nano-particle

The invention relates to a preparation method of two fluorescence mesoporous silica nano-particles, and belongs to the field of fluorescence nano-materials. According to the invention, an in-situ formation method is firstly adopted; 8-hydroxyquinoline is directly coordinated with zinc ions complexed in mesoporous silica, and conjugated polymer polyphenyleneethynylene precursor disulphonium salts are directly introduced into mesoporous silica nano-particles through an ion exchange process; and thus a fluorescence mesoporous silica nano-material is obtained with stable chemical and thermodynamic properties, which is a mesoporous silica nano-particle functionalized by 8-hydroxyquinoline and fluorescence conjugated polymer. Based on the high specific surface area, stable fluorescence performance, good dispersibility and biocompatibility of the fluorescence mesoporous nano-material, the prepared fluorescence mesoporous nano-material is applicable to biological aspects such as drug slow release, cell marking, gene vector, and the like.