Selective modified stripping voltammetric sensor based on Ce-1,4-benzenedicarboxylic metal–organic frameworks porous nanoparticles for picomolar detection of curcumin

Abstract A modified stripping voltammetric sensor based on porous nanoparticles from a Ce-1,4-benzenedicarboxylic (Ce-BDC) metal–organic framework (MOF) has been successfully fabricated for the detection of curcumin (CUR). Fabrication of porous nanoparticles of Ce-BDC acid MOF was carried out via the solvothermal method. The resulting MOF emerges with good crystallinity, octahedral-like morphology, and a specific surface area of 1020 m2 g−1, leading to an increase in reaction sites for the sensorand further enhanced performance. Cyclic voltammetry measurements utilizing 1.0% Ce-BDC–modified graphite paste sensor (MGPS) demonstrated a remarkable improvement in electrocatalytic activity and adsorption performance. Under standard detection conditions, the MGPS possessed a low limit of detection of 6 pM and wide linearity ranges of 0.02–2.0 (6.67 μA·nM−1) and 2.0–9.0 nM(1.65 μA·nM−1) for CUR using the square wave anodic stripping voltammetry method. Furthermore, the MGPS reveals proper accuracy, reproducibility, and storage stability, as well as anti-interference ability during the detection of CUR in biological fluids. The modified stripping voltammetric sensor was able to detect both co-mixed CUR and piperine concentrations, without interference during the analysis process.