Значение показателя IL-36y - потенциального биомаркера при псориатической эритродермии

Erythroderma is a rare and severe dermatological phenomenon caused by different diseases. The aim of the study was to analyze the value of IL-36γ immunohistology for the detection of psoriasis patients among those who suffer from erythroderma. The study was carried out on biopsy specimens from 56 erythroderma patients, who were treated in the department of dermatology of University Clinic of Bonn, Germany, and Skin and Venereology Clinic, the Leningrad region, between 2001 and 2013. Histological studies of the specimens were carried out for detection and classification of the underlying dermatosis, and Il36γ-immunohistology was studied. All the patients after histological analysis were divided into four groups. Group 1 included 17 patients with atopic erythroderma (eczema), group 2 consisted of 19 patients suffering from psoriasis, group 3 were 7 patients with T-cell lymphoma, and group 4 included 9 patients with drug reactions. Six patients were excluded from investigation as their histological pictures were nonspecific. Psoriasis patients showed a significantly higher expression of IL-36γ compared to other groups. The expression of IL-36γ was the most specific and sensitive marker, along with other histological criteria for the identification of psoriasis patients. Our results indicate that IL-36γ immunohistology is the most valuable marker for the detection of psoriasis in erythroderma patients. Psoriatic erythroderma can be rapidly diagnosed using this marker and specific therapy started.