Impact of Left Ventricular Assist Device Placement on Chronic Kidney Diseases: A Multicenter Longitudinal Study

Methods A retrospective multi-center cohort study was conducted, including all patients undergoing LVAD implantation. The Chronic Kidney Disease Epidemiology collaboration equation was used to determine the estimated glomerular filtration rate. Creatinine measurements were collected over a 2-year follow-up period. Patients stratification was based on their pre-operative CKD stage. Results Overall, 400 patients (mean age 52±14 years, 77% male) were included: 186 (47%) patients in CKD stage 1 & 2, 93 (23%) in CKD stage 3a, 82 (20%) in CKD stage 3b, and 39 (10%) patients were CKD stage 4 & 5. During a median follow-up of 458 days [141-1001], 46162 measurements of creatinine were available. Initial improvement of kidney function is noticed in every preoperative CKD stage group (P Conclusion Initial improvement of kidney function is noticed in all preoperative CKD stages. However, this improvement is of transient nature and the survival remains impaired in patients with diminished preoperative renal function.