Abstract 14256: The Prevalence and Prognosis of Early Repolarization and Brugada Electrocardiogram Pattern in Patients With Cardiovascular Risk Factors:Japan Morning Surge Home Blood Pressure (J-HOP) Study

Introduction: Patients at high risk for early repolarization (ER) and Brugada electrocardiogram patterns are also at high risk for sudden cardiac death. However, the prevalence and prognosis of ER and Brugada electrocardiogram (ECG) patterns in patients without ventricular fibrillation and with cardiovascular risk factors remains unclear. Hypothesis: We assessed the hypothesis that ER and Brugada ECG would be associated with cardiovascular events in Japanese patients with cardiovascular risk factors. Methods: Subjects were 3,128 patients enrolled in the Japan Morning Surge Home Blood Pressure Study who had one or more cardiovascular risk factors. An ER pattern was defined as J-point elevation of at least 0.1 mV from the baseline in at least 2 inferior or lateral leads. Brugada-type ECG was defined as follows: type 1, coved pattern: initial ST elevation ≥2 mm in V1/2; type 2: saddleback pattern in V1/2. The primary endpoints were death and nonfatal cardiovascular events (myocardial infarction, stroke, hospitalization for heart failure, aortic dissection). Results: During the mean follow-up period of 48±25 months, there were a total of 171 cardiovascular events. One thousand and sixty-eight patients had ER, 38 patients had type 1 Brugada ECG, and 41 patients had type 2 Brugada ECG. Patients with ER were older (64.9±10.7 vs. 63.7±10.6, p=0.003) and more likely to suffer cardiovascular events than patients without ER (N=2,049) (log rank 4.32, p=0.038). However, the difference of cardiovascular events was not statistically significant after adjusting for age and gender (p=0.11). Patients with type 1 Brugada ECG had a higher percentage of males (79% vs. 45%, p Conclusions: Early repolarization was not independently associated with poor prognosis, and Brugada-type ECG was not associated with poor prognosis.