Prediction of Transient Ischemic Attack and Minor Stroke in People with Type 2 Diabetes Mellitus

Abstract Aims People with type 2 diabetes (T2DM) have an increased risk of transient ischemic attack and minor stroke (TIA) which are frequently followed by an ischemic stroke. We aimed to develop a predictive model for incident TIA in people with T2DM. Methods We pooled data from two longitudinal cohort studies, Atherosclerosis Risk in Communities (ARIC) and the Cardiovascular Health Study (CHS), using a two-stage approach. First, we used a random effects model to interpolate risk factors of individuals between follow-up exams. Second, we used forward selection to develop a proportional hazards model for time to incident TIA. We internally validated our model using 10-fold cross-validation. Results Among 3,575 participants with T2DM, mean (SD) age was 60 (10) years and body mass index was 30 (6) kg/m2. Sixty-nine incident TIAs occurred during 38,364 person-years of follow-up. The multivariable model included age at diagnosis of diabetes (hazard ratio 1.13 (95% confidence interval: 1.05,1.21) per year), systolic blood pressure (1.25 (1.04,1.49) per 10 mmHg), a quadratic function of diastolic blood pressure, and history of congestive heart failure (2.08 (1.26, 3.42)). The median cross-validated Harrell’s C-index was 0.80. Conclusion Blood pressure and heart failure are risk factors for the earliest stages of cerebrovascular disease.