Three-Year Growth Hormone Treatment in Short Children with X-Linked Hypophosphatemic Rickets: Effects on Linear Growth and Body Disproportion

Context: Children with X-linked hypophosphatemic rickets (XLH) are prone to progressive disproportionate stunting despite oral phosphate and vitamin D treatment. Objective: Our objective was to analyze the effects of GH treatment on stature and lengths of linear body segments in short children with XLH. Design, Settings, and Patients: A 3-yr randomized controlled open-label GH study in short prepubertal children with XLH (n = 16) on phosphate and calcitriol treatment was conducted. A cohort of XLH patients (n = 76) on conservative treatment served as an XLH reference population. Main Outcome Measures: Changes in sd scores (SDS) of stature and linear body segments, i.e. sitting height, leg and arm length, and sitting height index (i.e. ratio between sitting height and stature) were the main outcome measures. Results: XLH patients presented at time of enrollment with significant impairments of stature (−3.3 SDS) and linear body segments compared with healthy children. Leg length (−3.8 SDS) was most impaired...