The role of Met, Src and Stat3 in basal-like breast cancer invasion

Background The basal-like subtype of human breast cancers has no clinically defined marker profile. Recent studies have shown that Met as well as certain Src family kinases are over-expressed in basal-like breast cancers and correlate with disease progression and poor prognosis. Our group has also demonstrated a potential regulatory role of Stat3 on Met activation or turnover, adding to the previously identified roles of Stat3.