The incidence and risk factors of urinary tract infection in patients with prostatic hyperplasia following invasive urodynamic investigation

Objective To investigate the incidence and related risk factors of urinary tract infection in patients with prostatic hyperplasia following urodynamic study. Methods A total of 540 patients with prostatic hyperplasia, who underwent urodynamic study in our hospital from January 2012 to June 2017 were recruited in this study. Before urodynamic study, urinalysis and bacterial culture was performed. Patients with negative results were selected for urodynamic study. Between 24 h and 48 h after the examination, urinalysis and urine culture were performed again to determine the incidence of urinary tract infection. The positive urine culture imply urinary tract infection.The patients' baseline characteristics and urodynamic parameters were analyzed. Results Among the 540 patients, urinary infection was found in 45 cases after the examination, the incidence was 8.33%. Comorbidity with diabetes, bladder outlet obstruction, post void residual (PVR), volume of prostate (Vp), maximal flow rate (Qmax) and average flow rate (Qav) were found to be the independent risk factors for urinary tract infection following urodynamic study.The most common pathogens were Escherichia coli and Enterococcus (51%, 20%). Conclusion Patients with diabetes mellitus, bladder outlet obstruction, high residual urine volume, large prostate volume, low maximum urinary flow rate, low average urinary flow rate, may need to be treated with prophylactic antibiotics to prevent postoperative urinary tract infection. It may be beneficial to start a short course of the prophylactic antibiotics treatment following urodynamic study. Key words: Urodynamic; Urinary tract infection; Risk factors