Ameliorative effect of resveratrol against thiacloprid induced acute and subacute toxicity in rats: Liver markers, renal markers and total protein

Thiacloprid, a neonicotinoid insecticide is known to target the nicotinic acetyl choline receptors (nACHRs) in insects and potentially in mammals. The aim was to ascertain the effect of acute (24h) and subacute (28 days) toxicity of thiacloprid and its amelioration by resveratrol in male Wistar rats. Liver and kidney function tests viz. ALT, AST, GGT, BUN, creatinine, were significantly increased while reduction in total protein levels were resulted from thiacloprid treatment which were significantly restored with resveratrol co-treatment in rats. The study revealed that thiacloprid possesses mild to moderate toxicity potential for hepatic and renal profile of adult male rats. Resveratrol possesses potential to sufficiently ameliorate the toxicity produced by thiacloprid and as such do not have any toxic effect at therapeutic doses in adult male wistar rats.