Fentanyl Therapy Controls Autonomic Hyperactivity in Tetanus

Sympathetic overactivity is a well-recognized complication of generalized tetanus in humans. In this clinical situation, a variety of drugs with primary or secondary actions on the cardiovascular system has been used with varying success. We show successful management of severe generalized tetanus in adults associated with autonomic hyperactivity with large doses of intravenous fentanyl.