Treatment of renal bone disease

Renal osteodystrophy is a disorder of bone and mineral metabolism that has long been recognized as a consequence of renal dysfunction. Disturbances in calcium and phosphorus homeostasis, reduced synthesis of 1,25-dihydroxyvitamin D3, altered metabolism of parathyroid hormone (PTH), impaired renal clearance of PTH fragments and accumulation of substances, such as aluminum and β2-macroglobulin, play a critical role in the pathogenesis of the renal bone diseases.