Heart Failure With Recovered Ejection Fraction in African Americans: Results From the African-American Heart Failure Trial

Abstract Background Recent studies have described the entity of heart failure with recovered ejection fraction (HFrecEF), but population-specific studies remain lacking. The aim of this study was to characterize patients enrolled in the African-American Heart Failure Trial (A-HeFT) who had significant improvement in their ejection fraction (EF) during the 1st 6 months of follow-up. Methods and Results Subjects with HFrecEF (improvement in EF from 40% in 6 months; n = 59) were compared with 259 subjects with heart failure and persistently reduced EF (HFrEF), defined as EF ≤40% at 6-month follow-up. The effects of improvement in EF on all-cause mortality and 1st and all hospitalizations were analyzed. Compared with HFrEF, subjects with HFrecEF had a nonsignificant trend toward lower mortality (hazard ratio [HR] 0.16, 95% confidence interval [CI] 0.02–1.15; P  = .068), fewer 1st HF hospitalizations (HR 0.22, 95% CI 0.07–0.71; P  = .011), fewer recurrent HF hospitalizations (HR 0.13, 95% CI 0.05–0.37; P  .001), similar 1st all-cause hospitalizations (HR 0.67, 95% CI 0.39–1.15; P  = .150), and fewer recurrent all-cause hospitalizations (HR 0.41, 95% CI 0.24–0.68; P  .001). Conclusions These data confirm that, as in other populations, a small subgroup of black patients receiving standard care improve their EF with favorable outcomes. Further studies are required to determine whether myocardial recovery is permanent and the best management strategies in such patients.