Genomic Association Analysis Identifies Multiple Loci Influencing Antihypertensive Response to an Angiotensin II Receptor Blocker

The interesting article by Turner et al1 concerns the pharmacogenomics of the angiotensin receptor blocker Candesartan and the validation of the associated single-nucleotide polymorphisms by their opposite direction associations with blood pressure response to hydrochlorothiazide. We are also performing a pharmacogenomic study of the angiotensin receptor blocker Losartan2 and hydrochlorothiazide in a slightly larger sample of white-only, essential hypertensives, carefully recruited …