Is it time to move to systematic antithrombotic prophylaxis or therapy for all patients with COVID-19 disease?

The coronavirus disease 2019 (COVID-19) has become one of the most tendentious diseases of the 21st century, responsible for more than 2,600,000 deaths worldwide since its declaration in Wuhan (province of Wubei, China) by the end of December 2019. The risk of thrombosis has been described as one of the most prominent features of COVID-19. However, the recommendations for therapeutic anticoagulation are addressed only for severe forms. A recent increase of sudden death in ambulatory patients with COVID-19 in Cameroon prompted us to discuss the possibility to move to anticoagulation for all patients with COVID-9. Thus, we suggest preventive anticoagulation for 14 days for mild forms of COVID-19. For moderate to critical forms, anticoagulation at a curative dose for at least 30 days, and up to 6 months in cases of pulmonary embolism, confirmed or with a high probability. Thus, large-scale randomized clinical trials with indisputable designs are needed.