GW29-e1504 Chronic restraint stress impairs ischemia-induced neovascularization through DPP-4-dependent pathway

The morbidity of lower extremity atherosclerotic disease(LEAD) has increased year by year. Chronic stress attenuates the ability of angiogenesis and deteriorates the prognosis of LEAD. Chronic stress increases plasma and tissue DPP-4 activities in mice. DPP-4 plays an important role in angiogenesis