MULTIPLE UN IT DOSAGE FORM - PELLET AND PELLETIZATION TECHNIQUES: AN OVERVIEW

Pellets have been used in the pharmaceutical industry for more than four decades, with the advent of controlled release technology, that the full impact of the inherent advantages of pellets over single unit dosage forms have been realized, not only has fo cused on refining and optimizing existing pelletization techniques, but also focused on the development of novel approaches and procedures for manufacturing of pellets. The present review outlines the manufacturing and evaluation of pellets. There are vari ous types of pelletization techniques like spheronization and extrusion, pelletization by layering, pelletization by solution layering & direct pelletization. The techniques namely extrusion - spheronization, hot melt extrusion, freeze pelletization, cryopel letization have been discussed along with parameters affecting pelletization.