Comment on Leelarathna et al. Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes. Diabetes Care 2020;43:e38-e39.

Leelarathna et al. (1) report a retrospective analysis linking the duration of hybrid closed-loop insulin therapy, using a single algorithm, with the achievement of stable sensor glucose metrics. They found that in adults with type 1 diabetes and baseline HbA1c ≥58 mmol/mol (≥7.5%), it takes 4 weeks to observe representative data for mean glucose and percentage time spent in normoglycemia and hyperglycemia. They also suggest that 6 weeks’ duration may be required for reliable estimates of hypoglycemia and glucose variability. This time may be required for control algorithm individualization and behavioral adaptation. We looked at the database built during the multicentric trial (WP7) that tested the Diabeloop DBLG1 hybrid closed-loop system in 63 adult patients with type 1 diabetes (baseline …