Two Cases of Interleukin-7–Deficient Generalized Verrucosis

We report two generalized verrucosis (GV) patients homozygous for a novel mutation in the start codon of IL7. Unlike the previous report in which IL-7 deficiency accompanied CD4 T lymphocytopenia, circulating CD4 T-cells were not depleted in one of our patients, suggesting a GV pathogenesis other than poor T-cell development.