Enterovirus Infections in Toronto during 1962.

Abstract Of 37 children from Toronto and surrounding districts who developed aseptic meningitis during summer 1962, 17 excreted Echo 9 virus in feces and/or cerebrospinal fluid, 12 of whom showed rising or elevated Echo 9 antibody levels in paired sera. A further two patients yielded Echo 14 virus from cerebrospinal fluid, one of whose feces also contained this virus, and both patients showed rising Echo 14 antibody titres. Morbilliform rashes without rhinitis or conjunctivitis were encountered in three Echo 9 excretors who had aseptic meningitis and in six patients without meningitis, three of whom yielded Echo 9 virus. Paralytic poliomyelitis was encountered in three patients, all of whom excreted polioviruses which showed aluminum marker characteristics of virulent strains. One Type III patient presented with twitching and left-sided hemiparesis. Febrile reactions accompanied by headache or other symptoms were observed in seven children who ingested Sabin trivalent poliovirus vaccine one to 17 days previously. All made complete clinical recoveries. Polioviruses with aluminum or temperature markers typical of attenuated vaccine strains were isolated from feces of all patients, including Type III from five patients, Type I from three patients and Type II from one patient.