AB1133 BACK TO THE BASICS: UNDERSTANDING THE PROGNOSTIC VALUE OF RHEUMATOID FACTOR AND ANTI-CYCLIC CITRULLINATED PEPTIDE IN RHEUMATOID ARTHRITIS FROM A MUSCULOSKELETAL ULTRASOUND PERSPECTIVE

Background: Anti-CCP and rheumatoid factor (RF), especially at high levels have been implicated as poor prognostic factors in rheumatoid arthritis (RA). With musculoskeletal ultrasound (US) being increasingly used for RA joint assessment, it is important to revisit the prognostic potential of these antibodies from an US perspective. Objectives: To study the prognostic value of RF and anti-CCP for poor disease outcomes, by investigating possible associations with US detected joint inflammation and erosion. Methods: In this cross sectional study, US power Doppler (PD) and grey scale (GS) joint inflammation were graded semi-quantitatively (0-3), while bone erosion was scored as either Yes=1 or No=0 at each joint recess. Patients disease activity was classified as either DAS28 25th, >50th and >75th percentiles. Results: 1080 joints and 1800 joint recesses from bilateral elbows, wrists, ankles and small joints of the hands and feet were scanned in 30 adult RA patients (76.7% Chinese and 93.3% female). Their baseline mean (SD) DAS28, disease duration, RF and anti-CCP levels were 3.58 (1.20), 70.3 (61.2) months, 142.1(179.0) IU/ml and 135.4(105.3) U/ml, respectively. Table 1 summarizes correlation coefficients of antibody levels with US variables. Among patients with DAS28 7 (75th percentile) was 0.72 (0.26, 0.97). For the anti-CCP level cutpoint of ≥95.2, specificity=53.8%, sensitivity=83.3%, accuracy=63.2%, Negative Predictive Value=87.5% and Positive Predictive Value=45.5%. Conclusion: The prognostic significance of anti-CCP and RF appears to differ in RA. Specifically, among patients with at least moderate disease activity (DAS28 ≥3.2), anti-CCP - but not RF - is associated with joint damage, being moderately correlated with US detected erosions. References: Nil: Disclosure of Interests: None declared