Abstract 19323: Extracellular Matrix Biomaterial Promotes Cardiac Repair Through an Active Bio-Inductive Fibroblast Growth Factor-2 Dependent Mechanism

Introduction: We previously demonstrated that epicardial application of extracellular matrix (ECM) biomaterial prevents LV remodeling and improves functional recovery following myocardial infarction (MI). In this study we aim to determine if the underlying mechanism of benefit is a consequence of the bio-inductive properties of the ECM biomaterial. Hypothesis: We hypothesize that ECM biomaterial will promote functional recovery after ischemic injury by stimulating vasculogenesis through a bio-inductive effect. Methods: Biologically active ECM biomaterial (CorMatrix-ECM) was compared to ECM biomaterial inactivated by chemical treatments. The paracrine response of human cardiac fibroblasts (N=6) to ECM biomaterial was characterized in vitro. In vivo active (N=16) or inactive (N=16) ECM biomaterial was surgically applied to the infarcted myocardium following coronary artery ligation in a rat model. Indices of cardiac performance were quantified by pressure volume loop analysis 14 weeks post-MI. Results: Huma...