CHRONIC PERINATAL HYPOXIA DELAYS CARDIAC MATURATION IN A MOUSE MODEL FOR CYANOTIC CONGENITAL HEART DISEASE

Cyanotic congenital heart disease (CHD) carries an increased risk of infant mortality and postoperative heart failure, as compared to acyanotic CHD. Transition from the hypoxic fetal milieu to the oxygen-rich postnatal environment is thought to drive normal cardiomyocyte maturation. We hypothesize