A novel anti-scar peptide for cutaneous wound repair

INTRODUCTION: Fibromodulin (FMOD) is required for fetal scarless healing and adult skin repair. Previously, we have demonstrated that FMOD not only augments dermal fibroblast migration and contraction to aid rapid wound closure and reduce scar size, but also enhances endothelial cell invasion to aid adequate angiogenesis. We aim to isolate the functional domain of FMOD responsible for the scar reduction properties and related cellular function, and adapt it for clinical use.