Efectele secundare posibile ale tratamentului cu bifosfonaţi la pacientele cu osteoporoză post-menopauză: dereglarea homeostaziei osoase şi osteonecroza de mandibulă

As a result of increased life expectancy, osteoporosis is a more and more frequent condition. The high risk of fractures determined an important interest about this pathology. Bisphosphonates are the mainstay of therapy for postmenopausal osteoporosis. Osteonecrosis of the jaw is a very serious side effect induced by the long-term aminobiphosphonate administration, which is associated with irreversible bone loss due to exposed necrotic bone. The illustration of a suggestive clinical case of a patient with breast cancer and postmenopausal osteoporosis, treated with zoledronic acid, is suggestive for the practitioner, emphasizing the importance of measures to properly monitor bisphos­pho­nate treatment for a favorable prognosis.