692 NON VIRAL RISK FACTORS IN DEVELOPMENT OF HCC AMONG EGYPTIAN CHRONIC LIVER DISEASE PATIENTS

Background and Aim: Diabetes was associated with twoto threefolds more with Hepatocellular carcinoma (HCC). We investigate the impact of comorbidity of diabetes on HCC presentation, progression and treatment outcome. Patients and Methods: Over 3 years, 1049 consecutive patients of HCC were evaluated; of them 347 patients were diabetics. The age, clinical features, aetiology of HCC and staging of the tumour at presentation, treatment decision and ultimate outcome were compared in diabetic to non-diabetic HCC patients. Results: HCC patients with DM (Group A, n =347, age = 60.3±7.3 years, sex (M:F) = 299:48) were compared with patient of HCC without DM (Group B, n = 702, age = 61.7±11.8 years, sex (M:F) = 608:94). Non alcoholic steatohepatitis was significantly more prevalent in Group A than Group B (p 0.05). Advanced HCC lesions were prevalent in group A than Group B (74.3 vs. 39.4%) – p < 0.05). During one year follow up, mortality rate was higher in Group A than Group B (60.2 vs. 45.3% – P < 0.05).