A COL1A1 Promoter-Controlled Expression of TGF-β Soluble Receptor Inhibits Hepatic Fibrosis Without Triggering Autoimmune Responses

Shouhua Zhang,Yuanqi Gong,Juhua Xiao,Yong Chai,Jun Lei,Hui Huang,Tianxin Xiang,Wei Shen

A COL1A1 Promoter-Controlled Expression of TGF-β Soluble Receptor Inhibits Hepatic Fibrosis Without Triggering Autoimmune Responses

2018

Shouhua Zhang
Yuanqi Gong
Juhua Xiao
Yong Chai
Jun Lei
Hui Huang
Tianxin Xiang
Wei Shen

Background Soluble TGF-β1 type II receptor (sTβRII) via TGF-β1 inhibition could inhibit hepatic fibrosis, but over-dosage triggers autoimmune responses.

Keywords:

Endocrinology
Autoimmune responses
Medicine
Internal medicine
Diabetes mellitus
Transforming growth factor
Cancer research
Autoimmunity
Fibrosis
Receptor
hepatic fibrosis

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