Immunoblastic Lymphadenopathy-Like T-Cell Lymphoma Displaying Rearrangement of Both IgH and TCRβ Genes after 4-Year Follow-Up of Idiopathic Eosinophilia

Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma (IBL-T) occurred in a 60-year-old female after a 4-year follow-up of idiopathic eosinophilia and upper pharyngeal inflammatory tumor with infiltration of mature eosinophils. Gene analysis of tumor cells revealed rearrangement of both IgH and TCRβ genes. The patient died of lymphoma seven months after the onset of the illness, in spite of chemotherapy against lymphoma. The relationship between eosinophilia and the pathogenesis of IBL-T, as well as the significance of the rearrangement of both IgH and TCRβ genes are discussed.(Internal Medicine 34: 418-423, 1995)