Abstract 16578: Two Cysteine S-nitrosylation Sites on the Cardiac Sodium Channel Are Responsible for Increased Late Sodium Current in Long QT Syndromes Type 9 & Type 12 but Not Type 3

Xuhua Chen,Jianding Cheng,John W. Kyle,Brandi Wiedmeyer,Graham S. Adsit,Carmen R. Valdivia,Alyson K. Fisher,Jonathan C. Makielski

Abstract 16578: Two Cysteine S-nitrosylation Sites on the Cardiac Sodium Channel Are Responsible for Increased Late Sodium Current in Long QT Syndromes Type 9 & Type 12 but Not Type 3

2017

Xuhua Chen
Jianding Cheng
John W. Kyle
Brandi Wiedmeyer
Graham S. Adsit
Carmen R. Valdivia
Alyson K. Fisher
Jonathan C. Makielski

Introduction: Direct S-nitrosylation (SNO) of cysteine in the cardiac sodium channel (NaV1.5) has been implicated in enhanced late sodium current (INaL) in Long QT syndromes type 9 (LQT9) and 12 (L...

Keywords:

Cysteine
Internal medicine
Sodium
Cell physiology
Diabetes mellitus
Cardiology
S-Nitrosylation
Medicine
Pharmacology
Sodium channel
Ion channel
sodium current

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