Non-invasive glucose monitor using dielectric spectroscopy.

Abstract: Objective The Alertgy noninvasive continuous glucose monitor (ANICGM) is a novel wristband device that reports glucose levels without entailing skin puncture. This study evaluated the performance of the ANICGM compared with an FDA-approved glucose meter in patients with type 2 diabetes. Methods The ANICGM device measures changes in the electromagnetic field generated by its sensor to produce a dielectric spectrum. The data contained within this spectrum are used in tandem with machine learning algorithms to estimate blood glucose (BG). Values from the ANICGM were collected, sent to the Alertgy lab, formatted, and compared to fingerstick BG measured using the Accuchek Inform II glucometer. Fifteen patients completed three 120-minute sessions. Mean absolute relative difference (MARD) was calculated. Results MARD values were compared for study Days 2 and 3. The MARD for Day 2 was 18.5% (95% CI: 12.8, 42.2%), and the MARD for Day 3 was 15.3% (95% CI: 12.3,18.4%). The difference in MARD between the two days was not statistically significant (P=0.210). Conclusions The result MARDs suggest that further investigation into the use of dielectric spectroscopy for glucose monitoring should be explored.