Effects of WY 47987 (Atrial Natriuretic Factor 102–126) in Patients with Renal Insufficiency: A Placebo-Controlled, Randomised Study

We studied renal, hormonal and cardiovascular effects of ANF 102-126 (WY 47987) in seven patients with chronic renal failure (serum creatinine 25-68 mg/l) and in four normal volunteers. ANF or placebo bolus injections were given at 1, 2 and 3 μg/kg i.v. (each dose on separate days)